{"id":339,"date":"2023-07-03T14:52:44","date_gmt":"2023-07-03T14:52:44","guid":{"rendered":"https:\/\/bioinformatika-egy.com\/?p=339"},"modified":"2026-01-28T16:07:58","modified_gmt":"2026-01-28T16:07:58","slug":"%d8%a7%d9%84%d9%85%d8%b9%d8%a7%d9%8a%d8%b1%d8%a9-%d8%a7%d9%84%d8%ad%d8%b1%d8%a7%d8%b1%d9%8a%d8%a9","status":"publish","type":"post","link":"https:\/\/bioinformatika-egy.com\/?p=339","title":{"rendered":"\u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629"},"content":{"rendered":"\n<p>\u0627\u0644\u0645\u0639\u0627\u064a\u0631 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 (ITC) \u0647\u0648 \u0637\u0631\u064a\u0642\u0629 \u0645\u062e\u062a\u0628\u0631\u064a\u0629 \u062a\u0642\u064a\u0633 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0645\u0646\u0628\u0639\u062b\u0629 \u0623\u0648 \u0627\u0644\u0645\u0645\u062a\u0635\u0629 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 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\u0627\u0644\u062d\u0631\u0627\u0631\u0629.<\/p>\n\n\n\n<p>\u2022 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u062d\u0631\u0627\u0631\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 (\u2206H): \u062a\u0642\u064a\u0633 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645\u0629 \u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0645\u0646\u0628\u0639\u062b\u0629 \u0623\u0648 \u0627\u0644\u062a\u064a \u064a\u0645\u062a\u0635\u0647\u0627 \u0627\u0644\u062a\u0641\u0627\u0639\u0644. \u064a\u0645\u0643\u0646 \u062d\u0633\u0627\u0628\u0647 \u0645\u0646 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u0630\u0631\u0648\u0629 \u0623\u0648 \u0645\u0633\u0627\u062d\u0629 \u0643\u0644 \u062d\u0642\u0646\u0629 \u0641\u064a \u0645\u0646\u062d\u0646\u0649 \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629.<\/p>\n\n\n\n<p>\u2022 \u0625\u0646\u062a\u0631\u0648\u0628\u064a\u0627 \u0627\u0644\u0631\u0628\u0637 (\u2206S): \u062a\u0642\u064a\u0633 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645\u0629 \u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628 \u0623\u0648 \u0627\u0644\u0646\u0638\u0627\u0645 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644. \u064a\u0645\u0643\u0646 \u062d\u0633\u0627\u0628\u0647 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u2206H \u0648\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 (\u0394T) \u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0639\u0627\u062f\u0644\u0629 \u062c\u064a\u0628\u0633 \u0644\u0644\u0637\u0627\u0642\u0629 \u0627\u0644\u062d\u0631\u0629: \u2206G = \u2206H &#8211; T\u2206S.<\/p>\n\n\n\n<p>\u2022 \u0627\u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0644\u0644\u0631\u0628\u0637 (n): \u062a\u0642\u064a\u0633 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645\u0629 \u0639\u062f\u062f \u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0643\u0644 \u062c\u0632\u064a\u0621 \u0643\u0628\u064a\u0631. \u064a\u0645\u0643\u0646 \u062d\u0633\u0627\u0628\u0647 \u0645\u0646 \u0646\u0642\u0637\u0629 \u0627\u0644\u062a\u0634\u0628\u0639 \u0623\u0648 \u0647\u0636\u0628\u0629 \u0645\u0646\u062d\u0646\u0649 \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0623\u0648 \u0645\u062a\u0633\u0627\u0648\u064a \u0627\u0644\u062d\u0631\u0627\u0631\u0629.<\/p>\n\n\n\n<p>\u2022 \u062d\u0631\u0643\u064a\u0629 \u0627\u0644\u0631\u0628\u0637 (k_on \u0648 k_off): \u062a\u0642\u064a\u0633 \u0647\u0630\u0647 \u0627\u0644\u0642\u064a\u0645 \u0645\u062f\u0649 \u0633\u0631\u0639\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u062f\u0648\u0627\u0626\u064a 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\u0648\u0622\u0644\u064a\u0629 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0648\u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u062f\u0648\u0627\u0626\u064a.<\/p>\n\n\n\n<p>\u2022 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646: \u0647\u0630\u0647 \u0647\u064a \u0639\u0645\u0644\u064a\u0629 \u062f\u0631\u0627\u0633\u0629 \u0643\u064a\u0641\u064a\u0629 \u062a\u0641\u0627\u0639\u0644 \u0627\u062b\u0646\u064a\u0646 \u0623\u0648 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0645\u0639 \u0628\u0639\u0636\u0647\u0627 \u0627\u0644\u0628\u0639\u0636. \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0639\u062f \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0641\u064a \u062a\u0648\u0635\u064a\u0641 \u0627\u0644\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u0627 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0648\u062d\u0631\u0643\u064a\u0629 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u060c \u0645\u062b\u0644 dimerization \u060c oligomerization \u060c \u0627\u0644\u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u0645\u0639\u0642\u062f \u060c \u0625\u0644\u062e.<\/p>\n\n\n\n<p>\u2022 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a: \u0647\u0630\u0647 \u0647\u064a \u0639\u0645\u0644\u064a\u0629 \u062f\u0631\u0627\u0633\u0629 \u0643\u064a\u0641\u064a\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u062a\u0633\u0644\u0633\u0644 \u0623\u0648 \u0628\u0646\u064a\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0639\u062f \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0641\u064a \u062a\u0648\u0636\u064a\u062d \u062e\u0635\u0648\u0635\u064a\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062a\u0648\u0627\u0641\u0642\u064a\u0629 \u0648\u062a\u0646\u0638\u064a\u0645 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0648\u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a.<\/p>\n\n\n\n<p>\u2022 \u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0625\u0646\u0632\u064a\u0645: \u0647\u0630\u0647 \u0647\u064a \u0639\u0645\u0644\u064a\u0629 \u062f\u0631\u0627\u0633\u0629 \u0643\u064a\u0641\u064a\u0629 \u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0644\u062a\u0641\u0627\u0639\u0644 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\u0648\u0635\u0642\u0644\u0647\u0627.<\/p>\n\n\n\n<p>\u0641\u064a \u0627\u0644\u062e\u062a\u0627\u0645 \u060c \u062a\u0639\u062f \u0627\u0644\u0645\u0639\u0627\u064a\u0631\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0637\u0631\u064a\u0642\u0629 \u0645\u0641\u064a\u062f\u0629 \u0648\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0627\u062a \u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0648\u0644\u0643\u0646\u0647\u0627 \u062a\u062a\u0637\u0644\u0628 \u0623\u064a\u0636\u0627 \u062a\u0637\u0628\u064a\u0642\u0627 \u0648\u062a\u0641\u0633\u064a\u0631\u0627 \u062f\u0642\u064a\u0642\u0627 \u0648\u0646\u0642\u062f\u064a\u0627.<\/p>\n\n\n\n<p><strong>\u0627\u0644\u0645\u0635\u0627\u062f\u0631:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Freyer, M. W., &amp; Lewis, E. A. (2008). Isothermal titration calorimetry: experimental design, data analysis, and probing macromolecule\/ligand binding and kinetic interactions.&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s43586-023-00199-x\" target=\"_blank\" rel=\"noreferrer noopener\">Methods in Cell Biology, 84, 79-113<\/a><\/li>\n\n\n\n<li>Velazquez-Campoy, A., &amp; Freire, E. (2006). Isothermal titration calorimetry to determine association constants for high-affinity ligands.&nbsp;<a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/sm\/d0sm01345e\" target=\"_blank\" rel=\"noreferrer noopener\">Nature Protocols, 1(1), 186-191<\/a><\/li>\n\n\n\n<li>Leavitt, S., &amp; Freire, E. (2001). Direct measurement of protein binding energetics by isothermal titration calorimetry.&nbsp;<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fctls.2022.906668\/full\" target=\"_blank\" rel=\"noreferrer noopener\">Current Opinion in Structural Biology, 11(5), 560-566<\/a><\/li>\n\n\n\n<li>Ladbury, J. E., &amp; Doyle, M. L. (2004). Biocalorimetry 2: applications of calorimetry in the biological sciences.&nbsp;<a href=\"https:\/\/www.azom.com\/article.aspx?ArticleID=12258\" target=\"_blank\" rel=\"noreferrer noopener\">John Wiley &amp; Sons<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0645\u0639\u0627\u064a\u0631 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 (ITC) \u0647\u0648 \u0637\u0631\u064a\u0642\u0629 \u0645\u062e\u062a\u0628\u0631\u064a\u0629 \u062a\u0642\u064a\u0633 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u0645\u0646\u0628\u0639\u062b\u0629 \u0623\u0648 \u0627\u0644\u0645\u0645\u062a\u0635\u0629 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u060c \u0645\u062b\u0644 \u0627\u0631\u062a\u0628\u0627\u0637 \u0645\u0631\u0643\u0628 \u062f\u0648\u0627\u0626\u064a \u0628\u062c\u0632\u064a\u0621 \u0643\u0628\u064a\u0631. \u062a\u0633\u062a\u062e\u062f\u0645 \u0647\u0630\u0647 \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0641\u064a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0648\u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u060c \u062d\u064a\u062b \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0648\u0641\u0631 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062d\u0648\u0644 \u0627\u0644\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u0627 \u0627\u0644\u062d\u0631\u0627\u0631\u064a\u0629 \u0648\u0627\u0644\u062d\u0631\u0643\u064a\u0629 \u0648\u0627\u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0644\u0644\u062a\u0641\u0627\u0639\u0644. \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0642\u0627\u0644 \u060c \u0633\u0623\u0634\u0631\u062d \u0627\u0644\u0645\u0628\u0627\u062f\u0626 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u0645\u0639\u0627\u064a\u0631\u0629 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-339","post","type-post","status-publish","format-standard","hentry","category-7"],"_links":{"self":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts\/339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=339"}],"version-history":[{"count":8,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts\/339\/revisions"}],"predecessor-version":[{"id":805,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts\/339\/revisions\/805"}],"wp:attachment":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=339"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=339"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}