{"id":682,"date":"2023-09-08T17:25:28","date_gmt":"2023-09-08T17:25:28","guid":{"rendered":"https:\/\/bioinformatika-egy.com\/?p=682"},"modified":"2026-01-28T16:07:59","modified_gmt":"2026-01-28T16:07:59","slug":"%d9%83%d9%8a%d9%81-%d8%aa%d9%83%d9%88%d9%86-%d9%87%d9%8a%d9%83%d9%84-%d8%af%d9%88%d8%a7%d8%a6%d9%8a-%d9%85%d8%b9%d9%82%d8%af-%d9%85%d9%86-%d8%a3%d8%ac%d8%b2%d8%a7%d8%a1-%d9%83%d9%8a%d9%85%d9%8a%d8%a7","status":"publish","type":"post","link":"https:\/\/bioinformatika-egy.com\/?p=682","title":{"rendered":"\u0643\u064a\u0641 \u062a\u0643\u0648\u0646 \u0647\u064a\u0643\u0644 \u062f\u0648\u0627\u0626\u064a \u0645\u0639\u0642\u062f \u0645\u0646 \u0623\u062c\u0632\u0627\u0621 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0628\u0633\u064a\u0637\u0629 \u063a\u064a\u0631 \u0645\u0631\u062a\u0628\u0629\u061f"},"content":{"rendered":"\n<p>\u0643\u064a\u0641 \u062a\u0643\u0648\u0646 \u0647\u064a\u0643\u0644 \u062f\u0648\u0627\u0626\u064a \u0645\u0639\u0642\u062f \u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0645\u0646 \u0623\u062c\u0632\u0627\u0621 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0628\u0633\u064a\u0637\u0629 \u063a\u064a\u0631 \u0645\u0631\u062a\u0628\u0629\u061f<\/p>\n\n\n\n<p>\u062a\u0645\u0627\u0645\u0627 \u0645\u062b\u0644 \u062a\u0631\u062a\u064a\u0628 \u0642\u0637\u0639 \u0627\u0644 puzzle \u062c\u0646\u0628\u0627 \u0627\u0644\u0649 \u062c\u0646\u0628 \u0644\u062a\u0643\u0648\u064a\u0646 \u0635\u0648\u0631\u0629 \u0645\u062a\u0643\u0627\u0645\u0644\u0647 \u0644\u0647\u0627 \u0645\u0639\u0646\u0649\u060c \u0641\u0642\u062f \u0627\u0635\u0628\u062d \u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u062a\u062c\u0645\u064a\u0639 \u0642\u0637\u0639 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u063a\u064a\u0631 \u0641\u0639\u0627\u0644\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0648 \u062a\u062d\u0648\u064a\u0644\u0647\u0627 \u0627\u0644\u0649 \u0645\u0631\u0643\u0628 \u0623\u0643\u062b\u0631 \u062a\u0639\u0642\u064a\u062f\u0627 \u0644\u0647 \u0641\u0627\u0639\u0644\u064a\u0629 \u0636\u062f \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0627\u0644\u0630\u064a \u062a\u0645 \u062a\u062d\u062f\u064a\u062f\u0647.<br>\u062a\u0633\u0645\u0649 \u0647\u0630\u0647 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0628\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0627\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0628\u0646\u064a \u0639\u0644\u0649 \u0627\u0644\u0634\u0638\u0627\u064a\u0627 (Fragment-based Drug Design; FBDD).<\/p>\n\n\n\n<p>\u0641\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0647\u064a\u0643\u0644 \u0627\u0644\u0641\u0631\u0627\u063a\u064a \u0644\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u0646\u0634\u0637 \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641 \u0643\u0642\u0627\u0644\u0628\u060c \u064a\u062a\u0645 \u062a\u0643\u0648\u064a\u0646 \u0645\u0631\u0643\u0628 \u062f\u0648\u0627\u0626\u064a \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062c\u0645\u064a\u0639 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 (\u0634\u0638\u0627\u064a\u0627 \u0623\u0648 Fragments) \u0628\u062d\u064a\u062b \u062a\u0643\u0648\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u062a\u0643\u0627\u0645\u0644\u0629 \u0641\u064a \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0641\u0631\u0627\u063a\u064a \u0645\u0639 \u0642\u0627\u0644\u0628 \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u0646\u0634\u0637\u060c \u0648 \u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u0635\u0628\u062d \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0646\u0647\u0627\u0626\u064a \u0628\u0639\u062f \u062a\u0631\u0627\u0628\u0637 \u0647\u0630\u0647 \u0627\u0644\u0623\u062c\u0632\u0627\u0621 \u0644\u0647 \u0642\u0627\u0628\u0644\u064a\u0629 \u0639\u0627\u0644\u064a\u0629 (Affinity) \u0644\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u0646\u0634\u0637 \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641.<\/p>\n\n\n\n<p>\u0645\u0624\u062e\u0631\u0627\u060c \u0642\u0645\u0646\u0627 \u064a\u062a\u0637\u0648\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0628\u062c\u0639\u0644 \u0627\u0644\u0645\u0648\u0642\u0639 \u0627\u0644\u0646\u0634\u0637 \u0647\u0648 \u0645\u0646 \u064a\u062e\u062a\u0627\u0631 \u0627\u0644\u0627\u062c\u0632\u0627\u0621 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0643\u0645\u0644\u0629 \u0644\u0647 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0639\u0631\u064a\u0636\u0647 \u0644\u0639\u062f\u0629 \u062a\u062c\u0627\u0631\u0628 \u0645\u0646 \u0627\u0644\u0645\u062d\u0627\u0643\u0627\u0629 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0627\u0644\u0637\u0648\u064a\u0644\u0629\u060c \u0648\u0645\u0646 \u062b\u0645 \u0642\u0645\u0646\u0627 \u0628\u062a\u062d\u0644\u064a\u0644 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 (Fragments) \u0644\u062a\u0634\u0643\u064a\u0644 \u062e\u0631\u064a\u0637\u0629 \u0647\u064a\u0643\u0644\u064a\u0629 \u0627\u0641\u062a\u0631\u0627\u0636\u064a\u0629 \u0644\u0644\u0647\u064a\u0643\u0644 \u0627\u0644\u0645\u0637\u0644\u0648\u0628 \u062a\u0635\u0645\u064a\u0645\u0647 \u0644\u064a\u0635\u0628\u062d \u062f\u0648\u0627\u0621\u0627 \u0645\u062d\u062a\u0645\u0644\u0627 \u0642\u0627\u062f\u0631\u0627 \u0639\u0644\u0649 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641. \u0623\u0637\u0644\u0642\u0646\u0627 \u0639\u0644\u0649 \u0647\u0630\u0647 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0633\u0645 &#8220;\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u064a \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u0634\u0638\u0627\u064a\u0627&#8221; \u0623\u0648 &#8220;Dynamic Fragment-based Drug Design; DFBDD&#8221;.<\/p>\n\n\n\n<p>\u0646\u0623\u0645\u0644 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0642\u0631\u064a\u0628 \u0623\u0646 \u0646\u0633\u062a\u0637\u064a\u0639 \u062a\u0637\u0648\u064a\u0631 \u0647\u0630\u0627 \u0627\u0644\u0627\u0633\u0644\u0648\u0628 \u0641\u064a \u062a\u0635\u0645\u064a\u0645 \u0623\u062f\u0648\u064a\u0629 \u0623\u0643\u062b\u0631 \u0627\u0646\u062a\u0642\u0627\u0626\u064a\u0629 \u0648 \u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0623\u0643\u062b\u0631 \u0623\u0645\u0627\u0646\u0627.<\/p>\n\n\n\n<p>\u062f\u0645\u062a\u0645 \u0628\u062e\u064a\u0631!<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u064a \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u0634\u0638\u0627\u064a\u0627&quot; - &quot;Dynamic Fragment-based Drug Design&quot;\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/B1A7CwVpUgc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u0631\u0627\u0628\u0637 \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0645\u0646\u0634\u0648\u0631:<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0141813023027137\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u0643\u064a\u0641 \u062a\u0643\u0648\u0646 \u0647\u064a\u0643\u0644 \u062f\u0648\u0627\u0626\u064a \u0645\u0639\u0642\u062f \u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0645\u0646 \u0623\u062c\u0632\u0627\u0621 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0628\u0633\u064a\u0637\u0629 \u063a\u064a\u0631 \u0645\u0631\u062a\u0628\u0629\u061f \u062a\u0645\u0627\u0645\u0627 \u0645\u062b\u0644 \u062a\u0631\u062a\u064a\u0628 \u0642\u0637\u0639 \u0627\u0644 puzzle \u062c\u0646\u0628\u0627 \u0627\u0644\u0649 \u062c\u0646\u0628 \u0644\u062a\u0643\u0648\u064a\u0646 \u0635\u0648\u0631\u0629 \u0645\u062a\u0643\u0627\u0645\u0644\u0647 \u0644\u0647\u0627 \u0645\u0639\u0646\u0649\u060c \u0641\u0642\u062f \u0627\u0635\u0628\u062d \u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u062a\u062c\u0645\u064a\u0639 \u0642\u0637\u0639 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u063a\u064a\u0631 \u0641\u0639\u0627\u0644\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0648 \u062a\u062d\u0648\u064a\u0644\u0647\u0627 \u0627\u0644\u0649 \u0645\u0631\u0643\u0628 \u0623\u0643\u062b\u0631 \u062a\u0639\u0642\u064a\u062f\u0627 \u0644\u0647 \u0641\u0627\u0639\u0644\u064a\u0629 \u0636\u062f \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0627\u0644\u0630\u064a \u062a\u0645 \u062a\u062d\u062f\u064a\u062f\u0647.\u062a\u0633\u0645\u0649 \u0647\u0630\u0647 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0628\u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0627\u062f\u0648\u064a\u0629 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-682","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts\/682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=682"}],"version-history":[{"count":3,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts\/682\/revisions"}],"predecessor-version":[{"id":817,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=\/wp\/v2\/posts\/682\/revisions\/817"}],"wp:attachment":[{"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioinformatika-egy.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}